Spurs' injury problems in attack are mounting, but the potential returns of Sanchez and Romero will at least ease their concerns on the defensive front before Tuchel's rampant forces pay a visit.
It is difficult to envisage Chelsea banking multiple goals in the capital if Santo has his first-choice backline available, but the visitors' own staunch rearguard action should shine through as they scrape a narrow win at the Tottenham Hotspur Stadium.